15 Questions for Evolutionists -- #5 How did new biochemical pathways originate?

Question 5 in CMI's '15 Questions for Evolutionists' flyer focuses on the silence from the evolutionary community regarding a naturalistic explanation for origin of complex biochemical pathways and nano-machines. This is another huge problem for evolution story (just like all the other questions in this series) requiring great faith on the part of those who believe evolution, in spite of the science against it.